Tag

Publication Archives - Page 3 of 5 - LUMICKS

hallo
New C-Trap™ Installed at the University at BuffaloUncategorised

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…
Santiago Gisler
5 September 2019
AFSUncategorised

New study maps internal and external structures of red blood cell aggregates by combining AFS™ and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…
Santiago Gisler
29 August 2019
Uncategorised

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS™

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…
Santiago Gisler
22 August 2019
Uncategorised

New insights into Cas9 off-target activity

The paper “DNA stretching induces Cas9 off-target binding and cleavage” was just published in Nature Structural and Molecular Biology. Congratulations to all the authors! In this paper, scientists at the MRC London Institute of Medical Sciences and AstraZeneca studied how CRISPR-Cas9 differentiates between on-targets and off-targets. They used the C-Trap®…
K.I.
8 March 2019
Newsletter pop up