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Uncategorised

Distal bridging between nucleosomes by polycomb complex PRC2 identified with the C-Trap®

A recent study published in PNAS used single-molecule force spectroscopy to examine unknown interaction mechanisms between polycomb repressive complex 2 (PRC2) and chromatin. The authors evaluated arrays of multiple nucleosomes using their C-Trap® optical tweezers system and identified distal nucleosome bridging by PRC2. The findings provide a better understanding of…
Santiago Gisler
3 December 2020
C-Trap® installed at Emory University in AtlantaUncategorised

C-Trap® installed at Emory University in Atlanta

We are happy to announce the installation of a new C-Trap® system with correlated optical tweezers and three-color confocal imaging functionality at Emory University in Atlanta, Georgia. The installed instrument, which is managed by the research group of Prof. Laura Finzi and Dr. David Dunlap, will be used by several…
Santiago Gisler
18 November 2020
Uncategorised

Researchers investigate the effects of biomolecular droplet structure on fusion times using the C-Trap®

In a recent publication, researchers at the University of Illinois at Chicago used the C-Trap® to study the relationship between structural properties of biomolecular condensates and their fusion times. They found that fusion times, an indicator of condensate density, varies depending on their structural organization. The findings highlight how physical…
Santiago Gisler
27 August 2020
Uncategorised

Electrostatic effects on vimentin stiffness demonstrated with the C-Trap®

A recently published study from the lab of Prof. Sarah Köster at the University of Göttingen investigated how electrostatic conditions influence the mechanical properties of intermediate filament vimentin, such as structural stability. The researchers assessed these features by stretching the protein in different buffer conditions, using the C-Trap® with correlated optical…
Santiago Gisler
6 August 2020
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