DNA-protein interactions (DPI) Archives

Blog posts

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

CRISPR-Cas9 represents one of the most impactful discoveries in the field of genetic engineering and medicine of recent times. Its discovery catalyzed a paradigm shift in the treatment approach to many genetic diseases, paving the way to simple and effective gene therapy for a large class of diseases. In fact, the…

Chenlu Yu5 December 2023

Blog posts

The C-Trap uncovers new insights into the mechanisms for ATP-dependent chromatin remodeling

PICH (Plk1-interacting checkpoint helicase) belongs to the SNF2 family of ATP-dependent chromatin remodelers. However, what makes PICH unique is that it lacks a nucleotide-binding domain despite having a great affinity for bare DNA. Because of this molecular structure, it has been hypothesized that the binding of PICH to chromatinized bridges…

Chenlu Yu13 June 2023

Blog posts

C-Trap^® experiments reveal novel mechanism for transcription termination in bacteria

New insights into the regulation of transcription termination have been revealed by researchers from the lab of Shixin Liu at The Rockefeller University, New York, in a recent publication in Molecular Cell. Using the powerful LUMICKS C-Trap® technology that allows the direct observation of molecular mechanisms, they were able to…

Chenlu Yu31 March 2023

Blog posts

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

In two recent scientific publications, Johannes Stigler and his team from the Gene Center of the Ludwig-Maximilians-University Munich, Germany, set out to mechanistically describe the action of the Structural Maintenance of Chromosome (SMC) Complexes using LUMICKS’ C-Trap® technology. By performing dynamic single-molecule experiments coupled with real-time visualization, they were able…

Chenlu Yu9 March 2023

C-Trap reveals mechanism of protein-DNA co-condensate formation.

Blog posts

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

In a recent publication in PNAS, researchers from the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) shed light on how proteins interact with individual DNA molecules to form co-condensates. Using LUMICKS’ C-Trap®, which combines optical tweezers, confocal microscopy, and…

Chenlu Yu16 March 2022

Blog posts

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Researchers from the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, led by Stephan W. Grill, have shed light on the physical nature of the interaction between the pioneer transcription factor Klf4 (Krüppel-like factor 4) and DNA. Using the C-Trap®, which combines optical tweezers, confocal microscopy…

Chenlu Yu23 February 2022

Blog posts

Newly formed Center for Optical Bio-Manipulation at the Niels Bohr Institute now equipped with an advanced C-Trap^® system

We’re overjoyed to announce the placement of one of our most sophisticated C-Trap® systems at the newly formed Center for Optical Bio-Manipulation (COBM) at the Niels Bohr Institute, University of Copenhagen! The center is based around LUMICKS' C-Trap system, flaunting quadruple optical tweezers, 3 color confocal fluorescence microscopy, and STED…

Adrià Ferragut13 July 2021

Blog posts

Advanced C-Trap^® systems recently installed at two universities in Europe

We are delighted to announce two new C-Trap® installations in Europe, one at the Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG) and the other at the University of Kent. At MPI-CBG, this will be the second C-Trap installed. The new system is configured with quadruple optical traps…

Adrià Ferragut6 July 2021

Blog posts

Two Chinese universities now equipped with a C-Trap^® system

We are very pleased to announce two new C-Trap® installations in China, one at the Microscopy Core Facility at Westlake University and one at the Institute of Advanced Studies at Soochow University. We begin with the group of Dr. Huizhong Xu at the Institute of Advanced Studies, Soochow University. Their…

Adrià Ferragut15 June 2021

Blog posts

Three C-Trap^® systems installed in the US East Coast

We are excited to share that three more institutes on the US East Coast are now equipped with a C-Trap® Optical Tweezers – Fluorescence Microscope! The three new instruments are now housed at a new core facility at MSKCC, at the NanoSystems Laboratory at the OSU, and at the UPMC-Hillman Cancer…

j.yeh17 May 2021

Join our newsletter

First Name

Last Name

E-mail address *

Country

Get exclusive news on the latest publications, product developments, events and breakthrough science.

Application of interest *

Dynamic single-molecule analysis

Cell avidity analysis

By submitting the form you agree to LUMICKS' privacy policy. You can revoke your consent at any time.

If you are human, leave this field blank.

Cookie	Duration	Description
Boxzilla	3 days	This cookie remembers if you have already closed a modal to make sure we don't show you the same information twice.
cookielawinfo-checkbox-advertisement	1 year	Set by the GDPR Cookie Consent plugin, this cookie is used to record the user consent for the cookies in the "Advertisement" category .
cookielawinfo-checkbox-analytics	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Analytics".
cookielawinfo-checkbox-functional	11 months	The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional".
cookielawinfo-checkbox-necessary	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookies is used to store the user consent for the cookies in the category "Necessary".
cookielawinfo-checkbox-others	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Other.
cookielawinfo-checkbox-performance	11 months	This cookie is set by GDPR Cookie Consent plugin. The cookie is used to store the user consent for the cookies in the category "Performance".
CookieLawInfoConsent	1 year	Records the default button state of the corresponding category & the status of CCPA. It works only in coordination with the primary cookie.
viewed_cookie_policy	11 months	The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. It does not store any personal data.

Cookie	Duration	Description
_ga	2 years	The _ga cookie, installed by Google Analytics, calculates visitor, session and campaign data and also keeps track of site usage for the site's analytics report. The cookie stores information anonymously and assigns a randomly generated number to recognize unique visitors.
_gat_gtag_UA_57399829_1	1 minute	Set by Google to distinguish users.
_gcl_au	3 months	Provided by Google Tag Manager to experiment advertisement efficiency of websites using their services.
_gid	1 day	Installed by Google Analytics, _gid cookie stores information on how visitors use a website, while also creating an analytics report of the website's performance. Some of the data that are collected include the number of visitors, their source, and the pages they visit anonymously.
Clarity		Clarity is a user behavior analytics tool that helps you understand how users are interacting with our website through session replays and heatmaps.
Google Analytics Universal	1 minute	A variation of the _gat cookie set by Google Analytics and Google Tag Manager to allow website owners to track visitor behaviour and measure site performance. The pattern element in the name contains the unique identity number of the account or website it relates to.
pardot	past	The pardot cookie is set while the visitor is logged in as a Pardot user. The cookie indicates an active session and is not used for tracking.
Pardot visitor	1 year	No description
Pardot visitor hashed	1 year	The Pardot cookie to link visitors to prospects

Cookie	Duration	Description
Cience		Tracking performance of Cience ads
Linkedin Insight		The LinkedIn Insight tag helps us keep track of conversions and traffic coming from the LinkedIn platform.
test_cookie	15 minutes	The test_cookie is set by doubleclick.net and is used to determine if the user's browser supports cookies.

DNA-protein interactions (DPI)

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

The C-Trap uncovers new insights into the mechanisms for ATP-dependent chromatin remodeling

C-Trap^® experiments reveal novel mechanism for transcription termination in bacteria

C-Trap^® experiments shed light on the mechanisms that govern Structural Maintenance of Chromosome (SMC) Complexes

C-Trap^® experiments reveal mechanism of protein-DNA co-condensate formation

C-Trap^® experiments reveal how a pioneer transcription factor interacts with DNA to regulate gene expression

Newly formed Center for Optical Bio-Manipulation at the Niels Bohr Institute now equipped with an advanced C-Trap^® system

Advanced C-Trap^® systems recently installed at two universities in Europe

Two Chinese universities now equipped with a C-Trap^® system

Three C-Trap^® systems installed in the US East Coast

Recent Posts

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

DNA-protein interactions (DPI)

Recent Posts

Tags

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

Accept cookies for the best website experience