Cas9 Archives - LUMICKS

Blog posts

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

CRISPR-Cas9 represents one of the most impactful discoveries in the field of genetic engineering and medicine of recent times. Its discovery catalyzed a paradigm shift in the treatment approach to many genetic diseases, paving the way to simple and effective gene therapy for a large class of diseases. In fact, the…

Chenlu Yu5 December 2023

C-Trap® installed at Imperial College London, UK

Blog posts

LUMICKS DSM technologies installed in South East UK

We are happy to share our news about the most recent C-Trap® and m-Trap® installations in the UK! We’ll start with the recently installed C-Trap system at the MRC-London Institute of Medical Sciences, Imperial College London that is used by the cell biologists and biochemists at the group of Prof. Luis…

Adrià Ferragut4 May 2021

Blog posts

Researchers use the m-Trap^® and C-Trap^® to discover CRISPR-Cas9 properties that can help improve in vivo efficiency

A recent publication from the research lab of Dr. Bo Sun presents new findings in the field of gene editing that may help improve in vivo delivery of CRISPR-Cas9 complexes. The team investigated the DNA-binding properties of Staphylococcus aureus Cas9 (SaCas9), a smaller orthologue to the commonly used Streptococcus pyogenes…

j.yeh10 September 2020

Blog posts

Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

A new publication shows how the lab of Dr. Bo Sun used the m-Trap® to analyze the interactions between a Cas9–gRNA complex and DNA. Using a single-molecule approach to unzip the target double-stranded DNA, the team showed interaction points on the DNA that affected Cas9 binding and cleavage. These results can…

j.yeh21 November 2019

Blog posts

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap^®

We are happy to announce that our application note Analyze Cas9 Binding and Cleavage Properties in Real Time while Manipulating DNA Structures is available to download on our website. In this application note, you can learn how the group of Prof. Dr. David Rueda used the C-Trap™ optical tweezers –…

j.yeh26 September 2019

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Cas9

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

LUMICKS DSM technologies installed in South East UK

Researchers use the m-Trap^® and C-Trap^® to discover CRISPR-Cas9 properties that can help improve in vivo efficiency

Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap^®

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Cas9

Towards safe and precise gene therapies: revealing the impact of DNA Supercoiling on CRISPR-Cas9 specificity

LUMICKS DSM technologies installed in South East UK

Researchers use the m-Trap® and C-Trap® to discover CRISPR-Cas9 properties that can help improve in vivo efficiency

Study finds essential Cas9–DNA interaction downstream of PAM using a single-molecule approach

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap®

Recent Posts

Tags

Applications

Products

About LUMICKS

For pricing, reach out to your application scientist or account manager

Fill in our contact form, we will reach out to you!

Join our newsletter

Download our webinar recording:

Download our Cell Therapy (CAR-T, TCR, NK) applications deck

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Researchers use the m-Trap^® and C-Trap^® to discover CRISPR-Cas9 properties that can help improve in vivo efficiency

New application note shows how to study Cas9 target specificity at the single-molecule level using the C-Trap^®