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Dynamic-single molecule analysis

Get a better understanding of dynamic single-molecule analysis, why is it important and relevant, and the working principle of our technology to measure and visualize biomolecular processes as they happen.

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Technologies

Correlated optical tweezers with fluorescence microscopy

The combination of optical tweezers and fluorescence microscopy allows for simultaneous manipulation and visualization of molecular interactions in real-time.

Technologies

What are optical tweezers?

Arthur Ashkin won the Nobel Prize in Physics “for the optical tweezers and their application to biological systems”. In essence, he discovered that light’s momentum could serve as an incredibly sensitive set of tweezers to catch and study biomolecules

Correlated microscopy methods

IRM (label-free)

IRM allows you to visualize microtubules without the need for fluorescence labeling

Correlated microscopy methods

TIRF

Suitable for visualization on surfaces as it eliminates background fluorescence outside the focal plane

Correlated microscopy methods

STED Super Resolution

STED nanoscopy allows you to distinguish between individual DNA-binding proteins in close proximity

Correlated microscopy methods

Confocal

The confocal microscope emits light by a laser through a pinhole that allows a specific light wavelength to pass

Correlated microscopy methods

Widefield

Widefield fluorescence microscopy illuminates the sample from below and uses light of frequencies that can excite fluorescent molecules associated to your sample

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