Single-molecule measurements with AFS® and optical tweezers reveal progressive assembly of viruses

The research lab of Dr. Gijs Wuite in the Netherlands recently published a single-molecule study in Science Advances, demonstrating the progressive self-assembly steps of viruses. Methods, such as optical tweezers and acoustic force spectroscopy (AFS®), enabled the researchers to study the transient and otherwise hard-to-verify steps associated with viral assembly.…
Santiago Gisler
14 May 2020

New study maps internal and external structures of red blood cell aggregates by combining AFS™ and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…
Santiago Gisler
29 August 2019

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS™

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…
Santiago Gisler
22 August 2019
C-Trap™ & AFS™ installed at Tianjin UniversityUncategorised

C-Trap™ & AFS™ installed at Tianjin University

LUMICKS is proud that Tianjin University, China, is now equipped with both a C-Trap™ Optical Tweezers-Fluorescence Microscopy and AFS™ Parallel Single-Molecule Force Spectroscopy. The systems are installed in the State Key Laboratory of Precision Measurement Technology and Instruments. Both systems will contribute to the research on processes involved in protein unfolding pathways. First, the…
Doenja Jansen
19 July 2019
AFS installation at GottingenUncategorised

AFS™ installed at University of Göttingen

An AFS™ system was installed in the lab of Professor Andreas Janshoff at the Department of Biophysical Chemistry at the University of Göttingen, Germany. Together with the team of Professor Claudia Steinem (Institute for Organic and Biomolecular Chemistry), the Janshoff group will use it to investigate the properties of and…
Doenja Jansen
4 April 2019
AFS installation at Victor Chang Cardiac Research Institute, AustraliaUncategorised

First AFS™ installed in Australia

The very first AFS™ Acoustic Force Spectroscopy-system in Australia has been successfully installed in the lab of Prof. Boris Martinac at the Victor Chang Cardiac Research Institute. Prof. Martinac and his team conduct research on cellular transduction processes associated with mechanosensitive ion channels. Although it has been shown that dysfunction of these ion channels contributes…
Doenja Jansen
12 March 2019

Single-Molecule Workshop at the Bustamante Lab (UC Berkeley)

The series of our successful single-molecule workshops continued on October 30 - November 1 at the Bustamante Lab (University of California, Berkeley). Both days started off with interesting seminars given by researchers from three top single-molecule labs. Dr. Shannon Yan (Bustamante Lab) presented her work studying co-transcriptional folding dynamics of a highly conserved…
Jerom Langeveld
16 November 2018
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