All Posts By

Santiago Gisler

hallo
New C-Trap™ Installed at the University at BuffaloUncategorised

Study establishes molecular forces responsible for condensation of ribonucleoprotein-RNA complexes

Researchers investigated the molecular driving forces underlying the condensation and decondensation of ribonucleoproteins using the C-Trap™. Specifically, they showed that sequence-dependent features of the RNA and ribonucleoprotein molecules partially dictate phase transitions. These findings can help scientists further understand the properties underlying eukaryotic liquid-liquid phase separation, or formation of membrane-less…
Santiago Gisler
5 September 2019
AFSUncategorised

New study maps internal and external structures of red blood cell aggregates by combining AFS™ and 3D imaging

Researchers used acoustic force spectroscopy (AFS™) in combination with 3D imaging to induce clustering and rotation of red blood cells, enabling them to study the properties of cell aggregates. The new approach, which is based on radiation and stream forces, allows researchers to retrieve 3D reconstructions of biologically relevant conditions…
Santiago Gisler
29 August 2019
Uncategorised

New study evaluates the dynamics behind viral assembly at the single-molecule level using both C-Trap™ and AFS™

Researchers used the C-Trap™ optical tweezers – fluorescence microscopy system and acoustic force spectroscopy (AFS) to study the processes underlying viral assembly. The study evaluated the capsid formation and DNA condensation of virus-like particles (VLPs) at the single-molecule level and in real time. The results serve to expand our understanding…
Santiago Gisler
22 August 2019
Department of Biochemistry, University of CambridgePress Releases

LUMICKS collaborates with AstraZeneca and the University of Cambridge to form the first ever Center of Excellence for Dynamic Single-Molecule Analysis for Accelerated Drug Discovery and Biology

The center will be based around LUMICKS’ C-Trap™ optical tweezers–fluorescence microscope, which for the first time enables real-time observation and probing of biomolecular interactions. The approach will be pioneered in several pharmacology and biology assays with the aim of accelerating the discovery of potential new drugs.
Santiago Gisler
27 June 2018
G2 product line launchPress Releases

LUMICKS launches new generation of dynamic single-molecule analysis instruments setting new standards for life-science research.

On February 17 we introduced our new generation of the C-Trap™ optical tweezers-fluorescence microscope and AFS™ Acoustic Force Spectroscopy system at the 62ndAnnual Meeting of the Biophysical Society in San Francisco. The new generation represents an evolution of LUMICKS’ original instruments, which set the benchmark for high-resolution and high-throughput single-molecule…
Santiago Gisler
16 February 2018
Newsletter pop up