Immuno-oncology

Improve the functional correlation of TCR T cells by replacing affinity measurements with avidity. Reveal TCR modified T cells with optimal avidity that improve T cell responses.

Compare the avidity of NK cells from different donors. Correlate the respective outcomes to effector cell functionalities, such as cell killing. Find NK cells with the optimal responses.

Test the binding avidity associated with different BsAb. Compare the avidity of T cells engaged by these BsAb and find the most desirable response.

Identify CARs that induce the “just-right” avidity. Fine-tune the desired avidities to avoid on-target/off-tumor binding. Select the optimally functioning CAR T cells based on their avidity.