Use avidity to identify the best NK cell with optimal response

Part of: Natural Killer cells

Use avidity to identify the best NK cell with optimal response

Glycostem researchers compared cell killing and cell avidity data of NK cells derived from two different donors (donor 1 and donor 2).

NK cells from donor 2 induced 3-fold higher cytotoxicity compared with  NK cells from donor 1 (74% and 24%, respectively). NK cells from donor 2 required higher forces than those from donor 1 to detach from target cells (Figure 5).

The data suggest that cell avidity is a reliable predictor of NK cell function and that cell avidity analyses can be applied to different types of immune cells.

5 Left: Cytotoxic effect of NK cells from donor 1 and donor 2 on the same population of target cells. Right: Avidity curve showing the proportion of target-bound NK cells upon application of a force ramp. (rForce indicates relative force).

Data courtesy of Glycosystem


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