Single-molecule visualisation of DNA repair mechanisms and non-homologous end joining (NHEJ)
DNA repair, the collection of highly regulated mechanisms by which a cell identifies and repairs DNA damage, remains one of the most essential processes of human life. Impaired DNA repair systems may lead to malignant mutations that jeopardize cellular well-being.
To study DNA repair, single-molecule studies have proven to
greatly enhance understanding at the molecular level. LUMICKS offers dynamic single-molecule analysis, a novel tool to identify which protein complexes are involved in the non-homologous end joining (NHEJ) DNA repair pathway and their mechanisms.
